Der PCR-Test: Der Gold-Standard in der Covid-Diagnostik?

von docmacher

Das Verwaltungsgericht Regensburg hat am 02.12. die Maßnahmen für die Stadt Passau bestätigt. Begründet wird die Entscheidung mit den Ergebnissen des PCR-Tests, der dem Gericht als – wörtlich – „Gold-Standard“ gilt. Ist das so? Welche Bedeutung hat der Test für die Diagnose von Covid19 wirklich.

Um die Antwort gleich vorwegzunehmen: Sie lautet „kommt drauf an“. Ob der Test brauchbar ist oder nicht, hängt von seiner Interpretation ab. Bisher wurde er völlig unkritisch angewendet und alle positiven Resultate als „infektiös“ gewertet. Dadurch wird die Zahl der wirklich infektiösen Personen massiv überschätzt. Woran das liegt, kann man in einem soeben erschienen Artikel einiger britischer Wissenschaftler nachlesen:

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1764/6018217

Gehen wir den Artikel der Reihe nach durch.

Zunächst wird erklärt, wie der Test funktioniert. Er beruht darauf, daß virale Nukleinsäure erkannt und durch das Enzym „Reverse Transkriptase“ zu größeren Molekülen aufgebaut wird. Der Test ist so empfindlich, daß er auch minimale Mengen Nukleinsäure erkennt. Mit jedem „Zyklus“ (Ct=cycle threshold) wird das Signal verstärkt. Das entscheidende ist nun, daß mit der Anzahl der Zyklen das infektiöse Potential des untersuchten Materials (Nasensekret, Rachenabstriche, Urin- und Stuhlproben) abnimmt. Der Leser wird sich jetzt vielleicht fragen, woher man weiß, ob das Material infektiös. Antwort: Man weiß es, wenn sich aus diesem Material in Zellkulturen Viren anzüchten lassen. Der PCR-test hingegen ist nicht in der Lage, zwischen kompletten Viren und nicht-infektiösen Fragmenten zu unterscheiden.

 

Die Autoren des oben erwähnten Artikels haben 29 Studien ausgewertet, in denen untersucht wurde, ob Viren anzüchtbar waren und in welchem Zusammenhang die Infektiösität zu den klinischen Symptomen der Patienten stand. Alle Studien stammen aus diesem Jahr.

 

Es zeigte sich, daß bei Material aus den Atemwegen die Anzüchtbarkeit gelang, wenn der Ct-Wert des PCR-Tests kleiner als 30 war. Bei Material von Patienten, die positiv getestet wurden, nachdem ein erster Test negativ war, gelang die Anzüchtung nie. Der Grund dafür ist vermutlich, daß die beim zweiten Test gefundene Menge an Nukleinsäure zu gering war oder von bereits abgestorbenen Viren stammte.

 

Ähnliche Resultate ergaben sich mit Material aus der Umgebung (z.B. Patientenzimmer oder verschiedene Bereiche eines Krankenhauses), aus Stuhl- und Urinproben, Abstrichen aus dem Nasen-Rachen-Raum und aus Blutproben: Der Ct-Wert lag über 30, Viren ließen sich nur selten anzüchten, aus Blutproben überhaupt nicht.

 

In 9 der ausgewerteten Studien wurde auch untersucht, wie lange virale RNA durch den PCR-Test erkannt werden kann. Diese Zeitspanne betrug mindestens sieben Tage, in einem Fall sogar 48 Tage. Wichtig ist hier der Vergleich mit der Zeitspanne, innerhalb der die Züchtung der Viren gelang, denn sie ist wesentlich kürzer, nämlich im Mittel 4 Tage, sofern der Ct-Wert unter 24 liegt.

 

Was bedeutet das? Es bedeutet, das, was wir sowieso schon über den PCR-Test wissen: Er findet kleinste Mengen Nukleinsäure, die nicht infektiös sind.

 

Genau aus diesem Grund weisen die Autoren auch darauf hin, daß im Zusammenhang mit dem Ergebnis eines PCR-Tests stets die klinische Symptomatik beachtet werden muß. Wünschenswert wäre eine Standard-Ct-Schwellenwert, oberhalb dessen Infektiösität ausgeschlossen werden kann.

Dies setzt allerdings die Standardisierung der auf dem Markt erhältlichen PCR-Tests voraus. Solange das nicht der Fall ist, kann aus einem positiven PCR-Test allein nicht der Schluss gezogen werden, daß die getestete Person infektiös ist.

 

Abschließend möchte ich noch auf die neuen Pläne des Hof-Virologen der Gott-Kanzlerin hinweisen: Er möchte sich künftig mit dem MERS (Middle East Respiratory Syndrome) befassen, das ja auch von Coronaviren verursacht wird. In einer Studie aus dem Jahre 2016 konnte das Virus zwar, wie zu erwarten, mittels PCR-Test nachgewiesen werden, war aber fast nie anzüchtbar.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108026/

 

Einige werden sich auch noch an Drostens Aussagen zur Schweinegrippe erinnern, z.B. hier:

https://www.sueddeutsche.de/wissen/schweinegrippe-die-welle-hat-begonnen-1.140006

 

Man muß kein Prophet sein um vorauszusagen, wie der Professor ohne Habilitation auf MERS reagieren wird...

 

Außerdem möchte ich jeden, der der englischen Sprache mächtig ist, ermutigen, in der Datenbank pubmed

https://www.ncbi.nlm.nih.gov/pmc/

selbständig zu recherchieren. Man findet dort vieles, was den einschlägigen Medien nicht bekannt ist oder von dem sie nicht wollen, daß es bekannt wird.

 

 

 

 

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Kommentar von T. Kranich |

Ob man Viren aus infizierten Proben (Sputum etc.) in vitro vermehren kann oder nicht mit der Infektiösität einer Person gleichzusetzen, ist schlichtweg Unsinn. Wird eine Person positiv getestet, ist es epidemiologisch am sinnvollsten, von einer Infektiösität auszugehen und die Person zu isolieren. Im besten Fall werden weitere Infektionen (und dadurch Krankheitsverläufe und Todesfälle, aber auch die Quarantäne anderer Personen!) vermieden. Im schlimmsten Falle wäre die Person nicht infektiös, muss aber ein paar Tage zu Hause sein. Zu sagen, dass eine "möglicherweise unnötige" Quarantäne schlimmer und wichtiger ist, als die grössere Wahrscheinlichkeit, dass Infektionen verhindert werden durch Quarantäne, ist schlichtweg nicht weitsichtig.

Liebe Grüsse

T. Kranich

Kommentar von Winfried Laba |

Machen wir uns nichts vor: Egal ob der PCR-Test Aussagekraft hat, oder nicht. Er scheint ein brauchbares Werkzeug zu sein, um den Massen die anstehende Diktatur des Antichristen zu "verkaufen".Man muss kein Mediziner sein, um zu merken, dass die ganze Pandemie zum Himmel stinkt.

Wenn die Geimpften reihenweise von der Immunreaktion ihres eigenen Körpers ins jenseits befördert werden, wird man seitens der Politik ganz betroffen sein.

Kommentar von Reiner |

T.kranich. Unsinn erzählen Sie.um sich zu infizieren,benötigen Sie eine gewisse Anzahl von Viren.sind Sie früher auch zum Testen gerannt bei Husten Schnupfen Heiserkeit? Seltsamerweise wird seit über einem Jahr überhaupt nicht darauf hingewiesen dass mir auch körpereigene Stärkung betreiben kann außer einer sogenannten Impfung die ich keinen empfehlen würde.

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Der PCR-Test: Der Gold-Standard in der Covid-Diagnostik? - docmacher

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My name is Eric and unlike a lot of emails you might get, I wanted to instead provide you with a word of encouragement – Congratulations

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Part of my job is to check out websites and the work you’ve done with docmacher.de definitely stands out.

It’s clear you took building a website seriously and made a real investment of time and resources into making it top quality.

There is, however, a catch… more accurately, a question…

So when someone like me happens to find your site – maybe at the top of the search results (nice job BTW) or just through a random link, how do you know?

More importantly, how do you make a connection with that person?

Studies show that 7 out of 10 visitors don’t stick around – they’re there one second and then gone with the wind.

Here’s a way to create INSTANT engagement that you may not have known about…

Talk With Web Visitor is a software widget that’s works on your site, ready to capture any visitor’s Name, Email address and Phone Number. It lets you know INSTANTLY that they’re interested – so that you can talk to that lead while they’re literally checking out docmacher.de.

CLICK HERE http://talkwithwebtraffic.com to try out a Live Demo with Talk With Web Visitor now to see exactly how it works.

It could be a game-changer for your business – and it gets even better… once you’ve captured their phone number, with our new SMS Text With Lead feature, you can automatically start a text (SMS) conversation – immediately (and there’s literally a 100X difference between contacting someone within 5 minutes versus 30 minutes.)

Plus then, even if you don’t close a deal right away, you can connect later on with text messages for new offers, content links, even just follow up notes to build a relationship.

Everything I’ve just described is simple, easy, and effective.

CLICK HERE http://talkwithwebtraffic.com to discover what Talk With Web Visitor can do for your business.

You could be converting up to 100X more leads today!

Eric
PS: Talk With Web Visitor offers a FREE 14 days trial – and it even includes International Long Distance Calling.
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Kommentar von Eric Jones |

My name’s Eric and I just came across your website - docmacher.de - in the search results.

Here’s what that means to me…

Your SEO’s working.

You’re getting eyeballs – mine at least.

Your content’s pretty good, wouldn’t change a thing.

BUT…

Eyeballs don’t pay the bills.

CUSTOMERS do.

And studies show that 7 out of 10 visitors to a site like docmacher.de will drop by, take a gander, and then head for the hills without doing anything else.

It’s like they never were even there.

You can fix this.

You can make it super-simple for them to raise their hand, say, “okay, let’s talk” without requiring them to even pull their cell phone from their pocket… thanks to Talk With Web Visitor.

Talk With Web Visitor is a software widget that sits on your site, ready and waiting to capture any visitor’s Name, Email address and Phone Number. It lets you know immediately – so you can talk to that lead immediately… without delay… BEFORE they head for those hills.

CLICK HERE https://jumboleadmagnet.com to try out a Live Demo with Talk With Web Visitor now to see exactly how it works.

Now it’s also true that when reaching out to hot leads, you MUST act fast – the difference between contacting someone within 5 minutes versus 30 minutes later is huge – like 100 times better!

That’s what makes our new SMS Text With Lead feature so powerful… you’ve got their phone number, so now you can start a text message (SMS) conversation with them… so even if they don’t take you up on your offer right away, you continue to text them new offers, new content, and new reasons to do business with you.

This could change everything for you and your business.

CLICK HERE https://jumboleadmagnet.com to learn more about everything Talk With Web Visitor can do and start turing eyeballs into money.

Eric
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Kommentar von Eric Jones |

Hello, my name’s Eric and I just ran across your website at docmacher.de...

I found it after a quick search, so your SEO’s working out…

Content looks pretty good…

One thing’s missing though…

A QUICK, EASY way to connect with you NOW.

Because studies show that a web lead like me will only hang out a few seconds – 7 out of 10 disappear almost instantly, Surf Surf Surf… then gone forever.

I have the solution:

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CLICK HERE http://jumboleadmagnet.com to discover what Talk With Web Visitor can do for your business, potentially converting up to 100X more eyeballs into leads today!

Eric
PS: Talk With Web Visitor offers a FREE 14 days trial – and it even includes International Long Distance Calling.
You have customers waiting to talk with you right now… don’t keep them waiting.
CLICK HERE http://jumboleadmagnet.com to try Talk With Web Visitor now.

If you'd like to unsubscribe click here http://jumboleadmagnet.com/unsubscribe.aspx?d=docmacher.de